Presentation of the integrator
MTInov was born in 2020 from the association of the Cell Therapy and Tissue Bank Unit of the Nancy CHRU and the Bioprocesses and Biomolecules research axis of the Reactions and Process Engineering Laboratory (CNRS, UL). This platform for studying, optimising and scaling up the production of cell-based biomedicines has expertise in cell culture in stirred bioreactors (on-line monitoring, intensification, modelling and design of bioreactors), as well as in the transfer to clinical grade in compliance with good manufacturing practices.
UTCT component (CHRU de Nancy)
The UTCT has expertise in cell therapy production and the production of advanced therapy medicinal products according to good manufacturing practices (GMP).
It is a department of the Nancy CHRU directed by Pr Danièle BENSOUSSAN (PU-PH). This service collaborates closely with the UMR CNRS 7365 IMoPA unit, the head of the UTCT being also co-leader with Pr MT Rubio of team 6 CECITA (Cellular Engineering, Cellular Immunotherapy and Translational Approaches) of the UMR 7365. In total, 5 hospital-academics of the UTCT (2 PU-PH, 2 MCU-PH and 1 AHU) are also affiliated to the UMR CNRS 7365, team 6. The UTCT has 7 technicians for hospital activities and 2 clinical research technicians financed on clinical research projects.
For several years, the UTCT has been positioned as the production unit for Innovative Therapy Medicines for the whole of the Grand Est region and has benefited from the support of the Grand Est Region and the Metropolis of Greater Nancy to develop its premises and equipment. At the same time, the UTCT has developed two innovative therapy drugs authorised or in clinical trials: anti-viral T lymphocytes and mesenchymal stem cells from the umbilical cord.
LRGP component (CNRS / University of Lorraine)
The LRGP (Reactions and Process Engineering Laboratory) has expertise in the development of cell culture processes in bioreactors.
It is a joint CNRS-University of Lorraine unit directed by Laurent Falk (DR CNRS). Within the Biopromo research axis, a team of 5 researchers and teacher-researchers and 5 technical staff dedicate part of their research activity to cell culture processes in bioreactors.