Publications in scientific journals and magazines

 

Below are the main publications of the last five years on the themes of biotherapies and human and animal cell culture in bioproduction, with platform staff as authors (names highlighted).

2023

Systematic Review on CAR-T Cell Clinical Trials Up to 2022: Academic Center Input

Wang, V., Gauthier, M., Decot, V., Reppel, L., and Bensoussan, D. (2023). Cancers 15, 1003. 10.3390/cancers15041003.

Dextran-based matrix functionalization to promote WJ-MSCs amplification: synthesis and characterization

Vandeberg, R., Grysan, P., Sion, C., Włodarczyk-Biegun, M. K., Lentzen, E., Bour, J., … & Grandfils, C. (2023). International Journal of Polymeric Materials and Polymeric Biomaterials, 72(4), 285-295.

2022

Comparison of partial least square, artificial neural network, and support vector regressions for real-time monitoring of CHO cell culture processes using in situ near-infrared spectroscopy

Zavala‐Ortiz, D.A., Denner, A., Aguilar‐Uscanga, M.G., Marc, A., Ebel, B., Guedon, E. (2022). Biotechnology and Bioengineering, 119(2), 535-549.

Wharton’s jelly-derived stromal cells and their cell therapy applications in allogeneic haematopoietic stem cell transplantation

Pochon, C., Notarantonio, A. B., Laroye, C., Reppel, L., Bensoussan, D., Bertrand, A., … & D’Aveni, M. Journal of Cellular and Molecular Medicine, 26(5), 1339-1350.

Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer

Reppel, L., Tsahouridis, O., Akulian, J., Davis, I. J., Lee, H., Fucà, G., … & Savoldo, B. (2022). Journal for Immunotherapy of Cancer10(1).

Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors

Fucà, G., Reppel, L., Landoni, E., Savoldo, B., & Dotti, G. (2020). Clinical cancer research26(11), 2444-2451.

Adverse Mechanical Ventilation and Pneumococcal Pneumonia Induce Immune and Mitochondrial Dysfunctions Mitigated by Mesenchymal Stem Cells in Rabbits

Blot, M., Jacquier, M., Pauchard, L. A., Rebaud, C., Marlin, C., Hamelle, C., …, Bensoussan, D., Reppel, L., Laroye, C., & Charles, P. E. (2022). Anesthesiology136(2), 293-313.

Impact of microcarrier concentration on mesenchymal stem cell growth and death: Experiments and modeling

Maillot, C., De Isla, N., Loubiere, C., Toye, D., & Olmos, E. (2022). Biotechnology and Bioengineering, 119(12), 3537-3548.

Delshadi, V. Massé, M. Fratzl, D. Kirk, T. Cerisy, C. Bonnais, P. Herviou, F. Daboussi, B. Ebel, E. Olmos, P. Kauffmann (2022). Innovatibe fast elisa for real-time monitoring of active principles : application to monoclonal antibody titration. 27th ESACT Congress, poster, juin 2022.

Maillot, C., Toye, D., De Isla, N., Olmos, E. (2022). Impact of microcarrier concentration on Mesenchymal Stem Cell expansion kinetics and quality attributes. 27th ESACT Congress, poster, juin 2022.

2021

Quality by design to define critical process parameters for mesenchymal stem cell expansion

Maillot, C., Sion, C., De Isla, N., Toye, D., & Olmos, E. (2021).  Biotechnology Advances, 107765.

Umbilical cord blood transplants facilitated by the French cord blood banks network. On behalf of the Agency of Biomedicine, Eurocord and the French society of bone marrow transplant and cell therapy (SFGM-TC)

Rafii, H., Garnier, F., Ruggeri, A., Ionescu, I., Ballot, C., Bensoussan, D., … & Gluckman, E. (2021). Bone Marrow Transplantation56(10), 2497-2509.

Natural Killer cells and monoclonal antibodies: Two partners for successful antibody dependent cytotoxicity against tumor cells

Gauthier, M., Laroye, C., Bensoussan, D., Boura, C., & Decot, V. (2021). Critical Reviews in Oncology/Hematology160, 103261.

A new perfusion mode of culture for WJ-MSCs expansion in a stirred and online monitored bioreactor

Sion, C., Ghannoum, D., Ebel, B., Gallo, F., de Isla, N., Guedon, E., Chevalot, I., & Olmos, E. (2021). Biotechnology and Bioengineering118(11), 4453-4464.

Dextran-based matrix functionalization to promote WJ-MSCs amplification: synthesis and characterization

Vandeberg, R., Grysan, P., Sion, C., Włodarczyk-Biegun, M. K., Lentzen, E., Bour, J., Krishnamoorthy, S., Olmos, E., & Grandfils, C. (2021). International Journal of Polymeric Materials and Polymeric Biomaterials, 1-11.

2020

Mesenchymal stromal cells for sepsis and septic shock: Lessons for treatment of COVID-19

Laroye, C., Gibot, S., Huselstein, C., & Bensoussan, D. (2020). Stem Cells Translational Medicine9(12), 1488-1494.

Are the Immune Properties of Mesenchymal Stem Cells from Wharton’s Jelly Maintained during Chondrogenic Differentiation?

Voisin, C., Cauchois, G., Reppel, L., Laroye, C., Louarn, L., Schenowitz, C., …, Bensoussan, D., & Huselstein, C. (2020). Journal of clinical medicine9(2), 423.

Effects of microcarriers addition and mixing on WJ-MSC culture in bioreactors

Sion, C., Loubière, C., Wlodarczyk-Biegun, M. K., Davoudi, N., Müller-Renno, C., Guedon, E., Chevalot, I., & Olmos, E. (2020). Biochemical Engineering Journal157, 107521.

Support Vector and Locally Weighted regressions to monitor monoclonal antibody glycosylation during CHO cell culture processes, an enhanced alternative to Partial Least Squares regression

Zavala-Ortiz, D.A., Ebel, B., Li M., Barradas-Dermitz, D.M., Hayward-Jones, P.M., Aguilar-Uscanga, M.G, Marc, A., Guedon, E. (2020). Biochemical Engineering Journal, 154, 107457.

2019

Interest of locally weighted regression to overcome nonlinear effects during in situ NIR monitoring of CHO cell culture parameters and antibody glycosylation

Zavala-Ortiz, D.A., Ebel, B., Barradas-Dermitz, D.M., Hayward-Jones, P.M., Aguilar-Uscanga, M.G, Marc A., Guedon, E. (2019). Biotechnology Progress, e2924.

Optimization of the Impeller Design for Mesenchymal Stem Cell Culture on Microcarriers in Bioreactors

Loubière, C., Delafosse, A., Guedon, E., Toye, D., Chevalot, I., & Olmos, E. (2019).  Chemical Engineering & Technology42(8), 1702-1708.

Mesenchymal Stem/Stromal Cell Production Compliant with Good Manufacturing Practice: Comparison between Bone Marrow, the Gold Standard Adult Source, and Wharton’s Jelly, an Extraembryonic Source

Laroye, C., Gauthier, M., Antonot, H., Decot, V., Reppel, L., & Bensoussan, D. (2019). Journal of clinical medicine8(12), 2207.

Dimensional analysis and CFD simulations of microcarrier ‘just-suspended’ state in mesenchymal stromal cells bioreactors

Loubière, C., Delafosse, A., Guedon, E., Chevalot, I., Toye, D., & Olmos, E. (2019). Chemical Engineering Science203, 464-474.

Impact of the type of microcarrier and agitation modes on the expansion performances of mesenchymal stem cells derived from umbilical cord

Loubière, C., Sion, C., De Isla, N., Reppel, L., Guedon, E., Chevalot, I., & Olmos, E. (2019). Biotechnology progress35(6), e2887.

Control of IgG glycosylation by in situ and real-time estimation of specific growth rate of CHO cells cultured in bioreactor

Li, M. Y., Ebel, B., Blanchard, F., Paris, C., Guedon, E., & Marc, A. (2019). Biotechnology and bioengineering116(5), 985-993.

Bone marrow vs Wharton’s jelly mesenchymal stem cells in experimental sepsis: a comparative study

Laroye, C., Boufenzer, A., Jolly, L., Cunat, L., Alauzet, C., Merlin, J. L., Yguel, C., Bensoussan, D., Reppel, L., & Gibot, S. (2019). Stem cell research & therapy10(1), 1-11.

Transfert adoptif de lymphocytes T
antiviraux et greffe de cellules souches
hématopoïétiques

Gauthier, M., Laroye, C., Bensoussan, D. (2019). Actualités en Onco-Hématologie, Review 2019.

2018

Clinical-grade mesenchymal stem cells derived from umbilical cord improve septic shock in pigs

Laroye, C., Lemarié, J., Boufenzer, A., Labroca, P., Cunat, L., Alauzet, C., …, Bensoussan, D., Reppel, L., & Gibot, S. (2018). Intensive care medicine experimental6(1), 1-14.

Adenovirus-specific T-lymphocyte efficacy in the presence of methylprednisolone: An in vitro study

Campidelli, A., Qian, C., Laroye, C., Decot, V., Reppel, L., D’aveni, M., & Bensoussan, D. (2018). Cytotherapy20(4), 524-531.

Real-time monitoring of antibody glycosylation site occupancy by in situ Raman spectroscopy during bioreactor CHO cell cultures

Li, M.-Y., Ebel, B., Chauchard, F., Guedon, E., Marc, A. (2018). Biotechnology Progress, 34, 486-493.

Parallel comparison of in situ Raman and NIR spectroscopies to simultaneously measure multiple variables toward real-time monitoring of CHO cell bioreactor cultures

Li, M., Ebel, B., Chauchard, F., Guedon, E., Marc A. (2018). Biochemical Engineering Journal, 137, 207-213.

Solid-liquid suspension of microcarriers in stirred tank bioreactor – Experimental and numerical analysis

Delafosse, A., Loubière, C., Calvo, S., Toye, D., & Olmos, E. (2018). Chemical Engineering Science180, 52-63.

Viral-specific T-cell transfer from HSCT donor for the treatment of viral infections or diseases after HSCT

Qian, C., Wang, Y., Reppel, L., D’aveni, M., Campidelli, A., Decot, V., & Bensoussan, D. (2018). Bone marrow transplantation53(2), 114-122.

2017

[Treatment by stem cell therapy of erectile dysfunction of diabetic origin: State of the art]

El Osta, R., Decot, V., Bensoussan, D., Stoltz, J. F., Eschwege, P., & Hubert, J. (2017). Progres en Urologie: Journal de L’association Francaise D’urologie et de la Societe Francaise D’urologie28(2), 74-84.

Modification of NK cell subset repartition and functions in granulocyte colony-stimulating factor-mobilized leukapheresis after expansion with IL-15

Xiong, Y., Mouginot, M., Reppel, L., Qian, C., Stoltz, J. F., Bensoussan, D., & Decot, V. (2017). Immunologic research65(6), 1130-1138.

Curative or pre-emptive adenovirus-specific T cell transfer from matched unrelated or third party haploidentical donors after HSCT, including UCB transplantations: a successful phase I/II multicenter clinical trial

Qian, C., Campidelli, A., Wang, Y., Cai, H., Venard, V., Jeulin, H., …, Decot, V., Reppel, L., …, & Bensoussan, D. (2017). Journal of hematology & oncology10(1), 1-14.

Concise Review: Mesenchymal Stromal/Stem Cells: A New Treatment for Sepsis and Septic Shock?

Laroye, C., Gibot, S., Reppel, L., & Bensoussan, D. (2017). Stem Cells35(12), 2331-2339.

Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation

Avercenc-Léger, L., Guerci, P., Virion, J. M., Cauchois, G., Hupont, S., Rahouadj, R., Magdalou, J., Stoltz, J.F., Bensoussan, D., Huselstein, C. & Reppel, L. (2017). Stem cell research & therapy8(1), 1-13.

Cryopreservation as a way to maintain extracorporeal photopheresis regimen for GvHD treatment while circumventing patient temporary inability to undergo apheresis

Pochon, C., Reppel, L., Halle, P., Zang, A., Clément, L., Michel, D., …, Decot, V., …, & Bensoussan, D. (2017). Bone marrow transplantation52(1), 167-170.

Revisiting MSC expansion from critical quality attributes to critical culture process parameters

Martin, C., Olmos, E., Collignon, M. L., De Isla, N., Blanchard, F., Chevalot, I., Guedon, E. (2017). Process Biochemistry, 59, 231-243.